反应详情

1-(2,2-Dimethylpropyl)-5-nitro-1H-1,2,3-benzotriazole (8) (4.46 g, 19.04 mmol, 1.0 equiv.) was dissolved in ethanol (50 ml) and flushed with N2, then charged with 10% Pd/C (2.026 g, 1.904 mmol, 0.1 equiv.). The mixture was sparged under an atmosphere of hydrogen (1 atm) and after stirring at room temperature for 5 hrs, the mixture was filtered through a Celite filter. The residue was washed with MeOH several times and the filtrate was concentrated in vacuo to give 1-(2,2-dimethylpropyl)-1H-1,2,3-benzotriazol-5-amine (9). LRMS m/z (M+H) 205.0 found, 205.3 required.

1. customflushed with N2
2. customThe mixture was sparged under an atmosphere of hydrogen (1 atm)
3. filtrationthe mixture was filtered through a Celite
4. filtrationfilter
5. washThe residue was washed with MeOH several times
6. concentrationthe filtrate was concentrated in vacuo