反应详情

1-(2,2-Dimethylpropyl)-5-nitro-1H-1,2,3-benzotriazole (4.46 g, 19.04 mmol, 1.0 equiv.) was dissolved in ethanol (50 ml), flushed with nitrogen, and charged with 10% Pd/C (2.026 g, 1.904 mmol, 0.1 equiv.). After sparging with nitrogen, the mixture was sparged with hydrogen (1 atm) and stirred at ambient temperature for 5 hours. The mixture was filtered through Celite, the residue was washed with methanol and the filtrate was concentrated in vacuo, providing the titled compound. LRMS m/z (M+H) 205.0 found, 205.3 required.

1. customflushed with nitrogen
2. customAfter sparging with nitrogen
3. customthe mixture was sparged with hydrogen (1 atm)
4. filtrationThe mixture was filtered through Celite
5. washthe residue was washed with methanol
6. concentrationthe filtrate was concentrated in vacuo