Acetic Acid → HCID 59355628, compound

Participants

Reaction Steps

An iron powder (4.33 g) was added to a mixture of acetic acid (0.5 ml), water (22 ml) and ethanol (34 ml) at room temperature, and thereto was added 5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-ethylnitrobenzene (5.60 g) obtained by Reference Production Example 29 at 75° C., and the mixture was stirred at the same temperature for 3 hours. After cooling to room temperature, the reaction mixture was filtrated and washed with ethyl acetate. To the filtrate was added an aqueous saturated sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain 5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazol-3-yl]-2-ethylaniline (5.20 g).

Provenance & Evidence