反应详情

温度

150 °C

To a mixture of compound D3 (2 g, 13.404 mmol) in EtOH (5 ml) was added chloroacetaldehyde (1.58 g, 20.11 mmol). The reaction mixture was subjected to microwave heating at 150° C. for 45 min. After cooling to room temperature, the solvent was evaporated in vacuo. The residue thus obtained was then treated with Et2O and a solid precipitated. The solid thus obtained was filtered off, washed with EtOAc and dried in vacuo to yield compound D21 (1.5 g, 70%).

1. temperatureAfter cooling to room temperature
2. customthe solvent was evaporated in vacuo
3. customThe residue thus obtained
4. customa solid precipitated
5. customThe solid thus obtained
6. filtrationwas filtered off
7. washwashed with EtOAc
8. customdried in vacuo
9. customto yield compound D21 (1.5 g, 70%)