1,2-Dichloroethane → HCID 58103892, compound

Participants

Reaction Steps

A solution of 2-piperazin-1-yl-pyrimidine hydrochloride (1.132 g, 4.773 mmol), in DCE (25 ml) was added to D41 (0.7 g, 3.977 mmol), sodium triacetoxy-borohydride (1.264 g, 5.966 mmol) and acetic acid (0.4 ml). The resulting mixture was stirred at r.t. for 1 day. Then, DMF (5 ml) was added and the reaction stirred for a further 16 h. at r.t. The reaction mixture was then diluted with NaHCO3 (aqueous sat. solution) and extracted with DCM. The organic layer was dried (MgSO4) and evaporated in vacuo.

Provenance & Evidence