HCID 68787685, compound → HCID 49834377, compound

Participants

Reaction Steps

A solution of 3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2-trifluoromethyl-phenyl]-acrylic acid methyl ester (preparation 1) in ethyl acetate (200 mL) containing Pd/C (500 mg) was hydrogenated overnight at rt. The catalyst was filtered off through Celite, and the filtrate was concentrated under reduced pressure to afford the title compound as a colorless oil, which was used without further purification. 1H NMR (300 MHz, DMSO) δ 7.92-7.83 (m, 2H), 7.54 (d, 1H), 3.62 (s, 3H), 3.06 (t, 2H), 2.70-2.61 (m, 2H), 1.31 (s, 12H).

Provenance & Evidence