HCID 68759633, compound → HCID 49834555, compound

Participants

Reaction Steps

A solution of (R)-3-[4-(3-oxo-cyclopentyl)-2-trifluoromethyl-phenyl]-acrylic acid ethyl ester (preparation 7, 1.55 g) in EtOAc (40 mL) containing Pd/C (300 mg) was hydrogenated overnight at rt. The catalyst was removed by filtration through Celite, and the filtrate was concentrated under reduced pressure, affording the title compound as a colorless oil. 1H NMR (300 MHz, CDCl3) δ 7.54-7.48 (m, 1H), 7.39-7.24 (m, 2H), 4.14 (q, 2H), 3.51-3.35 (m, 1H), 3.12 (t, 2H), 2.75-2.23 (m, 7H), 2.05-1.90 (m, 1H), 1.25 (t, 3H).

Provenance & Evidence