(1R)-1-(4-Fluoro-3-methoxyphenyl)ethan-1-amine → HCID 69670054, compound

Participants

Reaction Steps

General procedure A was followed using (S)-3-(4-hydroxy-3-trifluoromethyl-phenyl)-cyclopentanone (Preparation 10) as the ketone and (R)-1-(4-fluoro-3-methoxyphenyl)-ethylamine as the amine. 1H NMR (300 MHz, DMSO) δ 10.22 (bs, 1H), 7.39-7.20 (m, 2H), 7.19-7.04 (m, 2H), 6.96-6.84 (m, 2H), 3.82 (s, 3H), 3.73 (q, 1H), 3.26-2.79 (m, 2H), 2.24-1.27 (m, 7H), 1.23 (d, 3H).

Provenance & Evidence