Succinic anhydride → HCID 46867131, compound

Participants

Reaction Conditions

Reaction Steps

Into a solution of (N′-tert-Butoxycarbonyl-hydrazino)-acetic acid ethyl ester 4 (1.85 g, 18.5 mmol) in DMF (30 mL) was added succinic anhydride (4.84 g, 22.2 mmol) and the mixture was stirred at 75° C. for 18 h. DMF was evaporated and the crude mixture was purified by flash column chromatography using hexane:ethylacetate (1% acetic acid) as an eluent (yield 50%). 1H NMR (500 MHz, CDCl3) 1.28 (3H, CH2—CH3, t), 1.48 (9H, C—CH3, s), 2.55-3.00 (6H, NH—CH2—CO, N—CH2—CH2—CO, m), 4.20 (2H, CH2CH3, q); MS Anal. Mol. Wt. 318.25 (M−1).

Provenance & Evidence