Abietyl alcohol → HCID 57345173, compound

HRID 1627237Notes

Reaction equation

HRID 1627237 reaction equation
CC(C1CC[C@H:15]2[C:6](=[CH:7][CH2:8][C@@H:9]3[C@:14]2([CH3:18])[CH2:13][CH2:12][CH2:11][C@:10]3([CH2:20]O)[CH3:19])C=1)C.C[C@]1(CO)C2[C@@](C)([CH:28]3[C:33](=[CH:34]C2)[CH:32]=[C:31](C(C)C)[CH2:30][CH2:29]3)CCC1.[CH3:43][C@:44]1(C(N)=O)[CH:57]2[C@@:48](C)(C3C(=C[CH2:56]2)C=C(C(C)C)CC3)C[CH2:46][CH2:45]1.C[NH:66]C([C@@]1(C)C2[C@@](C)(C3C(=CC2)C=C(C(C)C)CC3)CCC1)=O.C[C@]1(CNC)C2[C@@](C)(C3C(=CC2)C=C(C(C)C)CC3)CCC1.C(N(CC)C([C@@]1(C)C2[C@@](C)(C3C(=CC2)C=C(C(C)C)CC3)CCC1)=O)C.CC(C1C=CC2C3(C)C(CCC=2C=1)C(CN)(C)CCC3)C.C[C@]1(CN)C2[C@@](C)(C3C(CC2)=CC(C(C)C)=CC=3)CCC1.C[C@]1(CNC(=O)C)C2[C@@](C)(C3C(CC2)=CC(C(C)C)=CC=3)CCC1.C[C@]1(CNC(=O)C(F)(F)F)C2[C@@](C)(C3C(CC2)=CC(C(C)C)=CC=3)CCC1.C[C@]1(CNC(=O)C(Br)(Br)Br)C2[C@@](C)(C3C(CC2)=CC(C(C)C)=CC=3)CCC1.C(C1C=C2C([C@]3(C)C(CC2)[C@@](CNC(=O)C2C=CC=CC=2)(C)CCC3)=CC=1)(C)C>>[CH2:34]([NH:66][CH2:15][C@@:14]1([CH3:18])[CH:9]2[C@@:10]([CH3:19])([C:20]3[C:6]([CH2:7][CH2:8]2)=[CH:43][C:44]([CH:57]([CH3:48])[CH3:56])=[CH:45][CH:46]=3)[CH2:11][CH2:12][CH2:13]1)[C:33]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

12

Reactant 11

HCID 443474Abietyl alcoholHCID 6427963HCID 6427963, compoundHCID 57345061HCID 57345061, compoundHCID 57345062HCID 57345062, compoundHCID 57345063HCID 57345063, compoundHCID 57345064HCID 57345064, compoundHCID 57345169HCID 57345169, compoundHCID 57345170HCID 57345170, compoundHCID 57345171HCID 57345171, compoundHCID 57345172HCID 57345172, compoundHCID 131731674HCID 131731674, compound

Product 1

HCID 57345173HCID 57345173, compound

Procedure

Abietyl alcohol/GPR-8/[(1R,4aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthren-1-yl]methanol; abietylamine/GPR-3{[(1R,4aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthren-1-yl]methyl}amine; abieticamide/GPR-2/(1R,4aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthrene-1-carboxamide; N-methylabieticamide/GPR-6/(1R,4aR)—N,1,4a-trimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthrene-1-carboxamide; N-methylabietylamine/GPR-7/{[(1R,4aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthren-1-yl]methyl}(methyl)amine; N,N-diethylabieticamide/GPR-11/(1R,4aR)—N,N-diethyl-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthrene-1-carboxamide; N,N-diethylabietylamine/GPR-12{[(1R,4aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthren-1-yl]methyl}diethylamine; leelamine/[(1R,4aS)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl]methanamine; N-acetylleelamine/GPR-4L/N-{[(1R,4aS)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl]methyl}acetamide; N-trifluoroacetylleelamine/GPR-1L/N-{[(1R,4aS)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl]methyl}-2,2,2-trifluoroacetamide; N-tribromoacetylleelamine/GPR-5L/N-{[(1R,4aS)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl]methyl}-2,2,2-tribromoacetamide; N-benzoylleelamine/GPR-7L/N-(((1R,4aS)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methyl)benzamide; and N-benzylleelamine/GPR-8L/N-benzyl-1-((1R,4aS)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methanamine are provided according to aspects of the present invention.

Sources & evidence

ORD record
ord-03f25acfd73e4bc1b46d7a3953a6c937
Source dataset
uspto-grants-2014_07
Patent number
US08785502B2

Reaction notes

Loading…