Sodium Bicarbonate → HCID 86662223, compound

Participants

Reaction Steps

To a solution of triethylammonium 2-(4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-3-fluorobenz amido)ethane sulfonate (45 mg, 0.061 mmol) in water (3 mL) was added NaHCO3 (5.1 mg, 0.061 mmol). After stirring 4 h, the aqueous mixture was washed with Et2O (5 mL). The aqueous layer was concentrated in vacuo, and the residue was triturated with DCM-MeOH (2:1=v/v, 6 mL). The mixture was filtered through Celite™ and the filtrate was concentrated in vacuo to give the title compound (25 mg, 63%) as white solid. 1H NMR (400 MHz, CD3OD): δ 7.53-7.48 (m, 2H), 7.27 (s, 1H), 7.15 (d, 1H), 7.06 (t, 1H) 6.79 (t, 2H), 6.48-6.45 (m, 2H), 6.07-6.03 (m, 2H), 4.05 (s, 2H), 3.84 (t, 2H), 3.66 (s, 3H), 3.12 (t, 2H), 1.50 (s, 6H).

Provenance & Evidence