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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 16273Generated: October 26, 2026

2-Naphthol → 2-(3,4,5-Trimethoxyphenylamino)-6-(naphthalen-2-yloxy)pyrazine

https://huagongshe.com/reaction/16273

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-NaphtholHCID 8663—
Reactant2-(3,4,5-Trimethoxyphenylamino)-6-chloropyrazineHCID 11609049—
Product2-(3,4,5-Trimethoxyphenylamino)-6-(naphthalen-2-yloxy)pyrazineHCID 2487932938%

Reaction Steps

Using Method X, with 200 mg of 2-(3,4,5-trimethoxyphenylamino)-6-chloropyrazine (all amounts scaled accordingly) and 2-naphthol, 78 mg of the title compound were obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07737152B2
Source datasetuspto-grants-2010_06
ORD IDord-0eafb53a66c34eaab39cb84046766e22
Source noteuspto-grants-2010_06