Pyridine → HCID 66740717, compound

Participants

Reaction Steps

To a 0° C. solution of 5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-amine (93 mg, 0.26 mmol) and pyridine (0.05 mL, 0.52 mmol) in DCM (1.5 mL) was added 2-chloro-6-fluorobenzoyl chloride (0.050 g, 0.26 mmol) in DCM (0.5 mL). After stirring 2 h at ambient temperature, the reaction was quenched with water. The mixture was extracted with DCM (3×5 mL) and dried with MgSO4. The residue was purified by HPLC (10-99%, MeCN/H2O with 0.05% TFA) to afford the title compound (9 mg) as a white solid. MS (EI) m/z 516 [M+H]+.

Provenance & Evidence