Potassium Carbonate → HCID 86662260, compound

Participants

Reaction Steps

In a manner described previously, a mixture of 2,6-difluoro-4-hydroxybenzaldehyde (538 mg, 3.40 mmol), K2CO3 (705 mg, 5.10 mmol) and bromoacetonitrile (303 μL, 4.40 mmol) in DMF (9 mL) was reacted, processed and purified by flash chromatography (0 to 100% EtOAc/Hex) to provide 2-(3,5-difluoro-4-formylphenoxy)acetonitrile (553 mg, 83%). 1HNMR (400 MHz, CDCl3) δ10.24 (s, 1H), 6.75-6.52 (m, 2H), 4.85 (s, 2H).

Provenance & Evidence