反应详情

Under ice-cooling, a solution of 25.0 g (15.8 mmol) of 4-fluorobenzoyl chloride in 30 ml of ether was added dropwise to a mixture solution of 22.6 g (15.8 mmol) of 1-aminocyclohexanecarboxylic acid and 25.0 g (23.7 mmol) of sodium carbonate in 100 ml of ether and 300 ml of water, and the mixture was stirred at room temperature overnight. After the ether layer was separated, the aqueous layer was neutralized by concentrated hydrochloric acid under ice-cooling and the precipitated crystal was collected by filtration to obtain 27.7 g (66%) of the title compound.

1. temperatureUnder ice-cooling
2. customAfter the ether layer was separated
3. temperaturecooling
4. filtrationthe precipitated crystal was collected by filtration