tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylate → 1-(tert-Butoxycarbonyl)-3-[(4'-chlorobiphenyl-4-yl)methoxymethyl]piperidine
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([CH2:14][OH:15])[CH2:11][CH2:12][CH2:13]1.[Cl:16][c:17]1[cH:18][cH:19][c:20](-[c:23]2[cH:24][cH:25][c:26]([CH2:29][Cl:30])[cH:27][cH:28]2)[cH:21][cH:22]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([CH2:14][O:15][CH2:29][c:26]2[cH:25][cH:24][c:23](-[c:20]3[cH:19][cH:18][c:17]([Cl:16])[cH:22][cH:21]3)[cH:28][cH:27]2)[CH2:11][CH2:12][CH2:13]1Participants
3
Sources & evidence
- ORD record
- ord-9903e3cefb564b5cb2f5913f50e9332b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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