3-(Benzyloxy)-5-phenylpyridin-2-amine → 2-Amino-5-phenylpyridin-3-ol

HRID 1627523노트

반응식

HRID 1627523 반응식
C([O:8][C:9]1[C:10]([NH2:21])=[N:11][CH:12]=[C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:14]=1)C1C=CC=CC=1>CO>[NH2:21][C:10]1[C:9]([OH:8])=[CH:14][C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:12][N:11]=1

참가 물질

3

반응물 1

HCID 103787373-(Benzyloxy)-5-phenylpyridin-2-amine

생성물 1

HCID 211113862-Amino-5-phenylpyridin-3-ol수율 93%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 3-benzyloxy-5-phenyl-pyridin-2-ylamine (Example I-87, 3.27 g, 11.8 mmol) in methanol (30 mL) was added Pd(CH)2 (2.5 g, 2.37 mmol). The mixture was degassed and charged with hydrogen three times, and then stirred under hydrogen balloon for 5 h. The reaction was filtered through a celite pad, washed with methanol, and condensed. After high vacuum dry, 2-amino-5-phenyl-pyridin-3-ol was obtained (2.04 g, 93% yield). MS m/z 187 [M+1].

후처리

  1. customThe mixture was degassed
  2. additioncharged with hydrogen three times
  3. filtrationThe reaction was filtered through a celite pad
  4. washwashed with methanol, and condensed
  5. customAfter high vacuum dry

출처 및 근거

ORD 기록
ord-d109a0a479a648d58b7585966dfe398d
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08785632B2

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