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HRID1627585

反应详情

EQUATION

反应方程式

HRID 1627585 的结构方程式

REACTANTS

反应物

2
结构：C[C@@H](Oc1nc(Br)cnc1N)c1c(Cl)ccc(F)c1Cl
HCID11531027

未命名化合物

结构：CC(C)(C)OC(=O)n1cc(B2OC(C)(C)C(C)(C)O2)cn1
HCID16217654

tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate

C14H23BN2O4

PRODUCTS

生成物

1
结构：C[C@@H](Oc1nc(-c2cn[nH]c2)cnc1N)c1c(Cl)ccc(F)c1Cl
HCID11516171

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to procedure 3 using 5-bromo-3-[(R)-1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyrazin-2-ylamine and 4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazole-1-carboxylic acid tert-butyl ester. 1H NMR (400 MHz, DMSO-d6) δ 12.81 (s, 1H), 7.79 (s, 1H), 7.48 (m, 1H), 7.36 (t, 1H), 6.48 (q, 1H), 6.12 (s, 2H), 1.75 (d, 3H); LCMS: 368 [M+1]; c-Met Ki: 0.065 μM.