Pyridine → HCID 131730604, compound

HRID 1627705Notes

Reaction equation

HRID 1627705 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([C:26]([F:29])([F:28])[F:27])[CH2:13][CH2:12][N:11]([C:14]3[CH:19]=[CH:18][C:17]([CH2:20][NH2:21])=[C:16]([C:22]([F:25])([F:24])[F:23])[CH:15]=3)[CH2:10]2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.ClC1C=C[C:34]([C:35](Cl)=[O:36])=CN=1.[N:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1.C(Cl)[Cl:47]>>[Cl:47][C:45]1[N:40]=[CH:41][C:42]([CH2:34][C:35]([NH:21][CH2:20][C:17]2[CH:18]=[CH:19][C:14]([N:11]3[CH2:12][CH2:13][C:9]([C:4]4[CH:5]=[C:6]([Cl:8])[CH:7]=[C:2]([Cl:1])[CH:3]=4)([C:26]([F:29])([F:28])[F:27])[CH2:10]3)=[CH:15][C:16]=2[C:22]([F:23])([F:24])[F:25])=[O:36])=[CH:43][CH:44]=1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 27821656-Chloronicotinoyl ChlorideHCID 59453382HCID 59453382, compound

Product 1

HCID 131730604HCID 131730604, compound

Procedure

1-{4-[3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoro-methyl)phenyl}methanamine (0.1 g) and 6-chloronicotinic acid chloride (0.04 g) were dissolved in methylene chloride (5 mL), and then pyridine (0.03 g) was added thereto. The resulting mixture was stirred at room temperature for one hour. The solvent was evaporated off under reduced pressure, and the residue was then purified by a column chromatography to obtain the title compound (0.1 g).

Workup

  1. customThe solvent was evaporated off under reduced pressure
  2. customthe residue was then purified by a column chromatography

Sources & evidence

ORD record
ord-d4ca2468574247588ddf4a3c58a65405
Source dataset
uspto-grants-2014_07
Patent number
US08785647B2

Reaction notes

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