HCID 53251154, compound → HCID 53251156, compound

Participants

Reaction Steps

3-{5-[2-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-ethyl]-3-phenyl-1,2,4-triazol-1-yl}-propionitrile (28 mg, 0.075 mmol) was dissolved in 2 M of Ammonia in Methanol (15 mL) and hydrogenated on an H-cube through a column of Raney-Nickel (50 bar hydrogen, rt). The solvent was evaporated off. The crude product was purified by silica gel chromatography (Eluent: 10% MeOH, 10% triethylamine, 80% EtOAc). Yield: 10 mg (35%) of the title compound as a clear oil. LC-MS: m/z=377.3 (MH+), tR=0.81 min, Method C.

Provenance & Evidence