Hydroxylamine → HCID 15985846, compound

Participants

Reaction Steps

The above prepared solution of (E)-3-{1-[4-(1-Methyl-1H-pyrazol-4-yl)-benzenesulfonyl]-1H-pyrrol-3-yl}-acryloyl chloride hydrochloride was added to an aqueous hydroxylamine solution (50%, 105 mL, 1.78 mol) at 10-20° C. over a period of 20 min. After stirring for 90 min, the suspension was filtered and dried. The crude product (48.4 g) was suspended in a mixture of isopropanol (480 mL) and water (480 mL) and stirred at reflux for 1 h. After cooling to room temperature, the suspension was filtered and dried. The title compound was obtained as beige solid (28.1 g).

Provenance & Evidence