Tetrahydrofuran → HCID 49806098, compound

Participants

Reaction Steps

This compound was prepared according to the procedure C from methyl [2-methyl-4-(4-chlorophenyl)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-b]pyridin-3-yl]acetate (0.100 g; 0.269 mmol), LHMDS 1N in THF (0.305 mL; 0.305 mmol), 1-iodopropane (0.044 mL; 0.451 mmol) in DMF (3.8 mL) for 4 h. Purification by flash chromatography on silica gel using a gradient of ethyl acetate (5-15%) in heptane furnished 0.049 g (44%) of the title compound as a yellow solid.

Provenance & Evidence