Tetrahydrofuran → HCID 49805490, compound

Participants

Reaction Steps

This compound was prepared according to the procedure C from methyl [2-methyl-4-(4-chlorophenyl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-b]pyridin-3-yl]acetate (0.254 g; 0.66 mmol), LHMDS 1N in THF (0.727 mL; 0.727 mmol), 1-iodopropane (0.097 mL; 0.99 mmol) in DMF (2.6 mL) for 18 h. Purification by flash chromatography on silica gel using a gradient of ethyl acetate (3-30%) in heptane furnished 0.196 g (69%) of the title compound as a yellow oil.

Provenance & Evidence