反应详情

4-Methoxyphenylboronic acid (152 mg, 1.00 mmol), and Pd(dtbpf)Cl2 (6 mg, 0.01 mmol) were added to a reaction tube equipped with a magnetic stir bar. Under a positive flow of argon while stirring, surfactant solution (1.0 mL, 2 wt % TPGS-M-PEG-750 in water), 2,4,6-triisopropylbenzene (126 μL, 0.50 mmol), and Et3N (0.21 mL, 1.5 mmol) were added by syringe and stirred vigorously for 24 h. The reaction mixture was then diluted with brine and extracted with EtOAc. The solution obtained was dried over MgSO4 and concentrated by rotary evaporation. The residue was purified by flash column chromatography eluting with 5% CH2Cl2/hexanes to afford the product (137 mg, 88%) as a white solid.

1. customequipped with a magnetic stir bar
2. stirringstirred vigorously for 24 h
3. extractionextracted with EtOAc
4. customThe solution obtained
5. dry with materialwas dried over MgSO4
6. concentrationconcentrated by rotary evaporation
7. customThe residue was purified by flash column chromatography
8. washeluting with 5% CH2Cl2/hexanes