Hydrochloric Acid → HCID 58382350, compound

Participants

Reaction Steps

7-(1-(2-(tert-Butyldimethylsilyloxy)ethyl)-5-methoxy-1H-indol-3-yl)-1-methyl-6-tosyl-1,6-dihydropyrazolo[3,4-d]pyrrolo[2,3-b]pyridine (0.130 g, 0.212 mmol, prepared using U from Preparation #P.1.1 with (2-bromoethoxy)(tert-butyl)dimethylsilane) was dissolved in MeOH (5 mL) then HCl (37% aqueous, 0.15 g, 1.3 mmol) was added. The mixture was stirred at rt for about 15 min. The mixture was concentrated under reduced pressure to give 2-(5-methoxy-3-(1-methyl-6-tosyl-1,6-dihydropyrazolo[3,4-d]pyrrolo[2,3-b]pyridin-7-yl)-1H-indol-1-yl)ethanol (0.10 g, 91%): LC/MS (Table 2, Method b) Rt=2.19 min; MS m/z: 516 (M+H)+.

Provenance & Evidence