Tetrahydrofuran → HCID 58382099, compound

Participants

Reaction Conditions

Reaction Steps

In a round flask was added (4-(methylthio)phenyl)(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)methanamine (0.453 g, 1.067 mmol, prepared using AF from Preparation #AE.1 with 4-(methylthio)phenyl)magnesium bromide and AG) and THF (5 mL) and mixture was cooled to about 0° C. Oxone® (1.312 g, 2.134 mmol) in water (2 mL) was added and the mixture was stirred for about 1 h. The mixture was diluted with water (5 mL) and extracted with DCM (10 mL), dried over MgSO4 and concentrated to provide (4-(methylsulfonyl)phenyl)(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)methanamine (0.487 g, 100%): LC/MS (Table 2, Method c) Rt=1.25 min; MS m/z 457 (M+H)+.

Provenance & Evidence