1H-Imidazole-4-carbaldehyde → HCID 67498423, compound

Participants

Reaction Steps

A solution of (S)-2-amino-3-phenyl-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)propanamide (0.066 g, 0.20 mmol), 1H-imidazole-4-carbaldehyde (0.019 g, 0.20 mmol) in MeOH (2 mL) was heated to 55° C. for 15 min before addition of NaCNBH3 (0.038 g, 0.61 mmol) and let stir for 4 h. The crude mixture was then purified by RPHPLC to afford (S)-2-((1-methyl-1H-imidazol-4-yl)methylamino)-3-phenyl-N-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)propanamide (47.0 mg, 55%).

Provenance & Evidence