Dimethylformamide → HCID 178453113, compound

Participants

Reaction Steps

To a rt solution of 2.D (267 mg, 0.73 mmol) in DMF (2.5 mL) under N2 was added 5-(pyridin-3-yl)-1,3,4-oxadiazol-2-amine (available from Chemical Block Ltd.) (143 mg, 0.88 mmol) followed by triethylamine (available from Alfa Aesar) (255 μl, 1.82 mmol). After stirring at rt for overnight, the reaction was quenched with saturated NaHCO3, diluted with water, and extracted with EtOAc. After removal of organic solvent, purification by flash chromatography on silica gel using 0-10% MeOH/CH2Cl2 for elution to give 2.E as pale yellow syrup (159 mg, 43%).

Provenance & Evidence