Trifluoroacetic acid → HCID 67497465, compound

Participants

Reaction Steps

To a 25 ml flask was added (S)-tert-butyl 1-oxo-3-phenyl-1-(3-(pyridin-4-yl)isoxazol-5-ylamino)propan-2-ylcarbamate 3.3B (160 mg, 0.40 mmoles), 10 ml of CH2Cl2, and 5 ml of TFA. The reaction was stirred at room temperature for 3 hour at which time the solvent was removed with a stream of nitrogen. The crude material was then partitioned between 200 ml of DCM and 100 ml of saturated sodium bicarbonate. The organic solvent was removed by rotary evaporation to give (S)-2-amino-3-phenyl-N-(3-(pyridin-4-yl)isoxazol-5-yl)propanamide 3.3.C as a light yellow solid (100 mg, 81% yield).

Provenance & Evidence