Benzene → HCID 45788714, compound

Participants

Reaction Steps

A mixture of N-(cyanomethyl)isonicotinamide (0.665 g, 4.1 mmol) and phosphorus pentasulfide (1.8 g, 8.3 mmol) in benzene (5.00 ml, 56 mmol) was allowed to refluxed for 24 hours. The mixture was concentrated and the residue was purified by CombiFlash using 0-10% methanol/DCM to give 730 mg of 2-(pyridin-4-yl)thiazol-5-amine 5.3C. 400 MHz 1H NMR (CD3OD) δ: 8.51 (d, J=8.0 Hz, 2H), 7.72 (d, J=8.0 Hz, 2H), 7.07 (s, 1H). LCMS (ES+) m/z 178.

Provenance & Evidence