Hydrochloric Acid → HCID 67496452, compound

Participants

Reaction Steps

tert-Butyl (S)-3-(4-fluorophenyl)-1-(1-methyl-3-(2-(methylamino)pyrimidin-4-yl)-1H-pyrazol-5-ylamino)-1-oxopropan-2-ylcarbamate, 9.E (0.12 g, 0.26 mmol) was treated with hydrogen chloride, 4.0 M solution in 1,4-dioxane (9.32 mg, 0.256 mmol) in 1,4-dioxane (3.0 ml) at 50° C. for 1 h. LCMS showed that Boc group was removed from SM. The solvent was removed. The crude 9.F was used for next step without further purification. MS ESI (pos.) m/e: 370.1 (M+H)+.

Provenance & Evidence