HCID 67497636, compound → HCID 136391026, compound

Participants

Reaction Steps

To a solution of (S)-2-amino-N-(2-(benzyloxy)-5-(pyridin-4-yl)phenyl)-3-phenylpropanamide 13.F (200 mg, 0.473 mmol) in methanol (2 mL) was added 10% Pd on carbon by weight (50 mg). The air was evacuated from the reaction flask and was replaced with hydrogen. The resulting slurry was stirred overnight at room temperature. The reaction mixture was filtered and the mother liquor condensed. The crude material was purified by reverse phase preparative HPLC to afford (S)-2-amino-N-(2-hydroxy-5-(pyridin-4-yl)phenyl)-3-phenylpropanamide 13.G (100 mg, 63% yield).

Provenance & Evidence