HCID 67496855, compound → HCID 67497335, compound

HRID 1628231Notes

Reaction equation

HRID 1628231 reaction equation
[CH3:1][O:2][C:3]1[C:8]([NH:9][C:10](=[O:29])[C@@H:11]([NH:19][C:20]2([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)[CH2:22][CH2:21]2)[CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][C:6](C2C=CN=CC=2)=[CH:5][N:4]=1.COC1C(N)=CC([C:45]2[N:49]([CH:50]3[CH2:55][CH2:54][CH2:53][CH2:52][O:51]3)[N:48]=[CH:47][CH:46]=2)=CN=1>>[CH3:1][O:2][C:3]1[C:8]([NH:9][C:10](=[O:29])[C@@H:11]([NH:19][C:20]2([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)[CH2:22][CH2:21]2)[CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][C:6]([C:45]2[N:49]([CH:50]3[CH2:55][CH2:54][CH2:53][CH2:52][O:51]3)[N:48]=[CH:47][CH:46]=2)=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 67496855HCID 67496855, compoundHCID 67497023HCID 67497023, compound

Product 1

HCID 67497335HCID 67497335, compound

Procedure

This example was made using the same general procedure as the synthesis of 11.1 starting with 2-methoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)pyridin-3-amine 14.1.C instead of 2-Methoxy-5-(pyridine-4-yl)pyridine-3-amine 11.1.B to give (2S)—N-(2-methoxy-5-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)pyridin-3-yl)-3-phenyl-2-(1-(pyridin-2-yl)cyclopropylamino)propanamide 14.1.D.

Sources & evidence

ORD record
ord-09d126fdbe9446eb8fb7e21b1b9aedec
Source dataset
uspto-grants-2014_07
Patent number
US08785468B2

Reaction notes

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