Trifluoroacetic acid → HCID 67496973, compound

Participants

Reaction Steps

To a 100 flask was added tert-butyl (S)-3-(4-fluorophenyl)-1-(1-methyl-3-(2-methylpyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxopropan-2-ylcarbamate TFA 16.1.E (529 mg, 0.93 mmole), 20 ml of DCM, and 10 ml of TFA. The reaction was stirred at room temperature for 12 hours at which time the solvent was removed to give (2S)-2-amino-3-(4-fluorophenyl)-N-(1-methyl-3-(2-methylpyridin-4-yl)-1H-pyrazol-5-yl)propanamide diTFA 16.1F as a yellow solid (560 mg 100% yield). LCMS ESI (pos.) m/e: 354.1 (M+1).

Provenance & Evidence