Diisopropylethylamine → HCID 67497930, compound

Participants

Reaction Steps

To a 250 ml flask was added 6.3 g of (S)-ethyl 2-(1-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxo-3-phenylpropan-2-ylamino)acetate 1.F, 1.8 g of Pd on carbon, 150 ml of MeOH and 2.8 ml of DIEA. The air was removed from the flask and replaced with hydrogen gas. This process was repeated four more times and then the reaction was stirred at room temperature for 2 hours, at which time the reaction was filtered over a bed of celite. The solvent was then removed and the crude was purified with a silica gel column (eluting with 2-5% MeOH in DCM) to give 4.5 g of (S)-ethyl 2-(1-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxo-3-phenylpropan-2-ylamino)acetate as a sticky solid.

Provenance & Evidence