Hydrochloric Acid → HCID 131731690, compound

Participants

Reaction Steps

To a 20 ml vial was added 800 mg of 17.8.B, 15 ml of dioxane, 10 drops of water and 4.5 ml of hydrogen chloride (2.0 M solution in diethyl ether). After 16 hours 10 ml of concentrated HCl were added and stirred at room temperature for 16 hours. The solvent was removed with a stream of nitrogen (dried with MeOH) to give 740 mg of 2-((S)-1-(3-(2-chloropyridin-4-yl)-1-methyl-1H-pyrazol-5-ylamino)-1-oxo-3-phenylpropan-2-ylamino)acetic acid diHCl salt as a light yellow solid (Note: trace methyl ester was observed in final product).

Provenance & Evidence