Dichloromethane → HCID 67496302, compound

Participants

Reaction Steps

To a solution of tert-butyl (S)-3-(4-fluorophenyl)-1-(4-methyl-2-(2-methylpyridin-4-yl)thiazol-5-ylamino)-1-oxopropan-2-ylcarbamate (0.061 g, 0.13 mmol) in DCM (0.0083 ml, 0.13 mmol) was added TFA (0.01 ml, 0.13 mmol). The resulting mixture was allowed to stir at rt overnight. The mixture was concentrated and the residue was purified by HPLC to give 40 mg of (2S)-2-Amino-3-(4-fluorophenyl)-N-(4-methyl-2-(2-methylpyridin-4-yl)thiazol-5-yl)propanamide 22E. 400 MHz 1H NMR (CD3OD) δ: 8.63 (d, J=8.0 Hz, 1H), 8.28 (br s, 1H), 8.22 (dd, J=8.0, 4.0 Hz, 1H), 7.31 (dd, J=8.0, 4.0 Hz, 2H), 7.09 (dd, J=8.0, 8.0 Hz, 2H), 4.51 (dd, J=8.0, 8.0 Hz, 1H), 3.30 (obscured dd, 1H), 3.23 (dd, J=16.0, 8.0 Hz, 1H), 2.80 (s, 3H), 2.43 (s, 3H). LCMS (ES+) m/z 371.

Provenance & Evidence