HCID 86664828, compound → HCID 67497326, compound

HRID 1628256Notes

Reaction equation

HRID 1628256 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:12]=[C:11]([NH2:13])[N:10]([CH3:14])[N:9]=2)[CH:5]=[CH:4][N:3]=1.[NH2:15][C:16]1NN=C(C2C=CN=C(NC)C=2)C=1>>[NH2:13][C:11]1[N:10]([CH3:14])[N:9]=[C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:15][CH3:16])[CH:7]=2)[CH:12]=1

Participants

3

Reactant 2

HCID 86664828HCID 86664828, compoundHCID 178482070HCID 178482070, compound

Product 1

HCID 67497326HCID 67497326, compoundYield 79%

Procedure

This title intermediate was prepared starting from 23.A (2.10 g, 10.0 mmol) according the procedure described above for conversion of 18.0 to 18.D. The crude product was purified by flash chromatography using 0-10% MeOH/CH2Cl2 for elution to provide 23.B as white solid (1.61 g, 79%).

Workup

  1. customThe crude product was purified by flash chromatography
  2. washfor elution

Sources & evidence

ORD record
ord-71db85fd8d334e30b56879e7f0db2253
Source dataset
uspto-grants-2014_07
Patent number
US08785468B2

Reaction notes

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