Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromoacetonitrile | HCID 11534 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 67496348 | HCID 67496348 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 86664830 | HCID 86664830 | 85.1% |
Reaction Steps
To a rt solution of 23.D (750 mg, 2036 μmol) and bromoacetonitrile (244 mg, 2036 μmol) in acetonitrile was added n,n-diisopropylethylamine (426 μl, 2443 μmol). After stirring at 60° C. for 2 hr, organic solvents were removed under reduced pressure. Purification of the residue by flash chromatography on silica gel using 0-12% MeOH/CH2Cl2 for elution gave the title product 23.E as yellow syrup (706 mg, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08785468B2 |
|---|
| Source dataset | uspto-grants-2014_07 |
|---|
| ORD ID | ord-4d796b2918a34eba805097114adb00b8 |
|---|
| Source note | uspto-grants-2014_07 |
|---|
