Hydrochloric Acid → HCID 67497525, compound

Participants

Reaction Steps

Crude 25.1.C was stirred in DCM with HCl (4.0 M, dioxane) until the deprotection was complete. The reaction mixture was concentrated to a solid and partitioned with saturated NaHCO3(aq)/CHCl3:IPA (4:1). The aqueous layer was further extracted (2×) and the organics were combined, dried with sodium sulfate, filtered, and concentrated to give a light tan solid (230 mg, 47%).

Provenance & Evidence