Imidazole → HCID 67497565, compound

Participants

Reaction Steps

Starting material 2-(5-amino-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-1-yl)ethanol 30.A was prepared analagously to example 23.1. To a flask with 30.A (306 mg, 1.3 mmol) was added DMAP (16 mg, 0.13 mmol), 1H-imidazole (268 mg, 3.9 mmol). Then DMF 1.5 mL was added, followed by tert-butylchlorodiphenylsilane (505 mg, 1.8 mmol). The reaction was stirred overnight. Standard aqueous workup and silica gel chromatography afforded 618 mg (100%) 30.B.

Provenance & Evidence