HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 6-(pyridin-4-yl)indoline TFA salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 6-(pyridin-4-yl)indoline-1-carboxylate | HCID 69620888 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-(pyridin-4-yl)indoline TFA salt | HCID 86664835 | 100% |
Reaction Steps
To a 100 ml flask was added tert-butyl 6-(pyridin-4-yl)indoline-1-carboxylate 50.B (202 mg, 0.68), 10 ml of CH2Cl2, and 5 ml of TFA. The reaction was stirred at room temperature for 2 hours at which time the solvent was removed to give 6-(pyridin-4-yl)indoline TFA salt 50.0 as a light yellow solid (300 mg, 100% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08785468B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-30c2f89b6e2a4c9fb1d61638afff5310 |
| Source note | uspto-grants-2014_07 |