HCID 67497043, compound → HCID 67496690, compound

HRID 1628294Notes

Reaction equation

HRID 1628294 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:9]=[C:10]([NH2:17])[CH:11]=[C:12]([N+:14]([O-])=O)[CH:13]=2)[CH:5]=[CH:4][N:3]=1>CO.[Pd]>[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[C:12]([NH2:14])[CH:11]=[C:10]([NH2:17])[CH:9]=2)[CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 1

HCID 67497043HCID 67497043, compound

Product 1

HCID 67496690HCID 67496690, compoundYield 91%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

To a rt solution of 51.1B (1.10 mg, 4.8 mol) in MeOH (10 mL) was added 5% Pd/C. The heterogeneous solution was stirred at 50° C. under H2 for 4.0 hr. To the resulting mixture was added celite, solid was filtered off and washed with MeOH. The combined liquid was concentrated under reduced pressure to provide the title product 51.1C as colorless solid (865 mg, 91%).

Workup

  1. additionTo the resulting mixture was added celite, solid
  2. filtrationwas filtered off
  3. washwashed with MeOH
  4. concentrationThe combined liquid was concentrated under reduced pressure

Sources & evidence

ORD record
ord-f742faefde4f4870a607373327a9c3ad
Source dataset
uspto-grants-2014_07
Patent number
US08785468B2

Reaction notes

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