Trifluoroacetic acid → HCID 86664838, compound

Participants

Reaction Steps

To a 100 ml flask containing (S)-tert-butyl 1-oxo-1-(4-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-6-(pyridin-4-yl)indolin-1-yl)-3-phenylpropan-2-ylcarbamate was added 20 ml of DCM and 10 ml of TFA. The reaction was stirred at room temperature for 6 hours at which time the solvent was removed with a stream of nitrogen to give (S)-5-(1-(2-amino-3-phenylpropanoyl)-6-(pyridin-4-yl)indolin-4-yl)-1,3,4-oxadiazol-2(3H)-one TFA salt 57.1.C (97 mg, 100% yield), which was used in the next step with no further purification.

Provenance & Evidence