Phosphorus oxychloride → 5-Bromo-2-chloro-3-nitropyridine

Participants

Reaction Conditions

Reaction Steps

To 5-bromo-3-nitropyridin-2-ol (78.A)(1 g, 5 mmol) was added 10 mL of phosphorus oxychloride. The reaction was heated at 100° C. for 1 hr., concentrated and worked up between EtOAc and saturated NaHCO3. The organic layer was concentrated, redissolved in DCM, filtered off the solids. The DCM layer was concentrated again to afford 450 mg (45%) of 78.B.

Provenance & Evidence