Trifluoroacetic acid → HCID 67497386, compound

Participants

Reaction Steps

The (S)-tert-butyl 1-oxo-3-phenyl-1-(6-(pyrimidin-5-yl)indolin-1-yl)propan-2-ylcarbamate (64 mg, 144 μmol) was dissolved in dichloromethane (1.0 mL) and TFA (1.0 mL, 13 mmol) was added. The resulting solution was stirred for three hours then concentrated. The residue was taken up in ethyl acetate and filtered and washed with hexanes to give the desired product (S)-2-amino-3-phenyl-1-(6-pyrimidin-5-yl-2,3-dihydro-indol-1-yl)-propan-1-one trifluoroacetate (50 mg, 76% yield) as the mono-trifluoroacetic acid salt. MS ESI (pos.) m/e: 345.1 (M+H).

Provenance & Evidence