Trifluoroacetic acid → HCID 67496508, compound

Participants

Reaction Steps

To a 50 ml flask was added tert-butyl (S)-1-(3-(2-methoxypyridin-4-yl)-1-methyl-1H-pyrazol-5-ylamino)-1-oxo-3-phenylpropan-2-ylcarbamate 105.1.D (0.99 g, 2.19 mmole) and 20 ml of dichloromethane. To the solution, 5 ml of trifluoroacetic acid was added. The reaction was stirred at room temperature for 2.5 hours at which time the solvent was removed by rotary evaporation. The residue was suspended in ethyl acetate, and washed successively with saturated sodium bicarbonate, water and brine. The organic layer was dried over anhydrous sodium sulfate, and concentrated in vacuo to give 105.1.E (706 mg, 92% yield) as yellow solid.

Provenance & Evidence