(Pyrimidin-5-yl)boronic acid → HCID 67497531, compound

Participants

Reaction Steps

The title compound was prepared from 107.1.B and pyrimidin-5-ylboronic acid according to the procedure described in Example 107.1.C. The crude product was purified to give 108.1.A (85 mg, 41% yield) as colorless crystals. 1H NMR (400 MHz, CDCl3) δ ppm 9.59 (s, 1H), 9.23 (s, 1H), 8.99 (s, 2H), 7.98 (t, J=1.9 Hz, 1H), 7.66-7.62 (m, 1H), 7.49 (t, J=8.0 Hz, 1H), 7.37-7.27 (m, 6H), 4.17-4.12 (m, 2H), 3.51 (dd, J=9.1, 4.1 Hz, 1H), 3.36 (s, 2H), 3.35 (dd, J=14.1, 4.3 Hz, 1H), 2.92 (dd, J=14.1, 9.0 Hz, 1H), 1.22 (t, J=7.2 Hz, 3H).

Provenance & Evidence