Ammonia → HCID 58204559, compound

Participants

Role	Name	HCID	Charge
Reactant	Ammonia	HCID 222	—
Reactant	2-[4-Cyano-1-(1-methylethyl)-1H-pyrazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-9-carboxylic acid	HCID 58204934	—
Product	HCID 58204559	HCID 58204559	—

Reaction Steps

Following Example 109, 2-(4-Cyano-1-isopropyl-1H-pyrazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-9-carboxylic acid from Example 16 was coupled with ammonia to give 138. Yield 27.8 mg (44%). MS(ESI):363.1. 1H NMR (400 MHz, DMSO) δ 8.46 (d, J=8.4, 1H), 8.11 (s, 1H), 8.00 (d, J=4.7, 2H), 7.62 (dd, J=8.4, 1.5, 1H), 7.57 (d, J=1.4, 1H), 7.44 (s, 1H), 5.46 (dt, J=13.1, 6.5, 1H), 4.59 (dd, J=17.5, 4.8, 4H), 1.48 (d, J=6.6, 6H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08785626B2
Source dataset	uspto-grants-2014_07
ORD ID	ord-e2bd813cee8c4209955e73975efbb47a
Source note	uspto-grants-2014_07