Ethyl Acetate → HCID 59343476, compound

Participants

Reaction Steps

Using Method DD with 2,6-dichloropyrazine (250 mg, 1.69 mmol) and 4-hydroxyisoquinoline (270 mg, 1.49 mmol), and purification by column chromatography (AcOEt:cyclohexane, 1:1), the title compound was obtained (263 mg). Yield: 61%. 1H NMR (250 MHz, DMSO-d6) δ 7.72-7.78 (m, 3H, Harom 3+6+7), 8.11 (d, 1H, Harom 5, J=7.8 Hz), 8.53 (d, 1H, Harom 2, J=5.9 Hz), 8.55 (s, 1H, HPz 5), 8.75 (s, 1H, HPz 3), 9.43 (s, 1H, Harom 8).

Provenance & Evidence